TEST REPETITION FROM THE VIEWPOINT OF BIOLOGICAL VARIATION

Purpose: The present study was set out to investigate the effect of test repetition within biological variation perspective by addressing reanalyzing an individual sample on total variation. This also demonstrated what extent a laboratory result reflects homeostatic set-point. Methods: values were determined for different coefficients analytical (CVA) corresponding optimum (CVA = 0.25 x CVI), desirable 0.5 and minimum CVI) limits performance specifications imprecision. number measurements single simulated. Furthermore, percentage closeness true setting point (D) commonly used 27 analytes. Results: showed that reduction with reanalysis lower than 19%, 10%, 3% tests meeting minimum, level specification limits, respectively. only 9.4%, 5.1%, 1.5% duplicate analysis at abovementioned limits. Conclusion: has negligible variation, especially when meets specifications. D reported in this can guide professionals clinicians about